Gimeracil CAS 103766-25-2 Purity >98.5% (T) (HPLC)
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Gimeracil (CAS: 103766-25-2) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Gimeracil (CAS: 103766-25-2), Please contact: alvin@ruifuchem.com
| Chemical Name | Gimeracil |
| Synonyms | Gimestat; 5-Chloro-2,4-Dihydroxypyridine; 5-Chloro-2,4-Pyridinediol; 5-Chloro-4-Hydroxy-2(1H)-Pyridinone; 5-Chloropyridine-2,4-Diol; 5-Chloro-4-Hydroxypyridin-2(1H)-one; CDHP |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 103766-25-2 |
| Molecular Formula | C5H4ClNO2 |
| Molecular Weight | 145.54 g/mol |
| Melting Point | 274℃(dec.) |
| Density | 1.56±0.10 g/cm3 |
| COA & MSDS | Available |
| Place of Origin | Shanghai, China |
| Caution | Not Intended for Human or Veterinary Use. For Research Use Only. |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | White or Off-White Crystallized Powder | White Crystallized Powder |
| Identifcation | UV; IR | Conforms |
| Loss on Drying | <0.50% | 0.15% |
| Residue on Ignition | <0.20% | 0.12% |
| Heavy Metals (Pb) | <20ppm | <10ppm |
| Related Substances | <1.00% | 0.43% |
| Gimeracil Purity | >98.5% (HPLC) | 99.57% |
| Infrared Spectrum | Conforms to Structure | Conforms |
| Conclusion | The product has been tested and complies with the given specifications | |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃), well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire, heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 2942000000 |
Gimeracil (CAS: 103766-25-2) is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD), which inhibits the early step in homologous recombination for double strand breaks repair. Antimicrobials and antitumors for research and experimental use.
Gimeracil is a pyridi derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines.
Gimeracil has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations. Furthermore, at 1 mM Gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy.
