Chlorotrimethylsilane (TMCS) CAS 75-77-4 Purity >99.0% (GC) Factory

Chlorotrimethylsilane (TMCS) (CAS: 75-77-4) is a valuable reagent for the protection of the hydroxyl function in organic synthesis. Chlorotrimethylsilane is a colorless fuming liquid with a pungent odor. Readily hydrolyzed with liberation of hydrogen chloride; soluble in benzene, ether and perchloroethylene. Chlorotrimethylsilane is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It is widely used in the syntheses of drugs. It have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis, and used for silylation and as a protection group in the process of various organic synthesis. Chlorotrimethylsilane is the most extensively used derivatization reagent for gas chromatography. The reactions are generally performed under anhydrous conditions although reactions can be performed on samples obtained from water-containing samples. There are considerable opportunities for artifacts stemming from a variety of reasons including off-target reactions with aldehydes and ketones. The rate of reaction of TMCS with nucleophilic targets is comparatively slow compared to other alkylsilyl chlorides and requires the presence of a base catalyst such as pyridine.